Indole-3-carbinol丨CAS 700-06-1

1. Nutraceuticals and Dietary Supplements

I3C is widely used as a dietary supplement to promote hormonal balance, especially in women's health.

Often marketed for PMS, menopause symptoms, and estrogen metabolism support.

Can be found in capsules, tablets, or blended with other phytonutrients like DIM (Diindolylmethane).

2. Cancer Prevention and Therapeutics

Chemopreventive agent: I3C is known to modulate phase I and phase II detoxifying enzymes, aiding in the metabolism and elimination of carcinogens.

It induces cell cycle arrest and apoptosis in various cancer cell lines, including breast, prostate, colon, and cervical cancers.

NF-κB pathway inhibition

3. Pharmaceutical Research

Used as a lead compound in the design and development of anti-cancer drugs and anti-inflammatory agents.

Investigated in combination therapies to enhance the efficacy of existing cancer treatments.

Studied for its role in immune modulation, oxidative stress reduction, and detoxification mechanisms.

4. Agricultural and Environmental Sciences

Explored as a biomarker for glucosinolate metabolism in plants.

Serves as a reference standard in research into plant-derived anticarcinogens.

Derived from common vegetables, making it attractive for use in functional foods and natural product-based formulations.

Promotes healthy estrogen metabolism, encouraging the production of beneficial estrogen metabolites like 2-hydroxyestrone over carcinogenic 16 -hydroxyestrone.

✅ Antioxidant and Anti-inflammatory

Reduces oxidative stress and inhibits inflammatory responses, contributing to overall cellular protection and disease prevention.

Shows promise in a range of conditions: hormone-sensitive cancers, autoimmune disorders, viral infections (e.g., HPV), and detoxification support.

Converts into Diindolylmethane (DIM) under acidic conditions in the stomach, which has complementary health effects.